Gnt1020630 – Mackay - Research Fellowship

Abstract

I am the leading scientist studying a factor named BAFF and discovered its role in autoimmunity. BAFF inhibitors are effective in late stage clinical trials treating lupus patients. Our new work shows that BAFF has other fascinating roles, in particular the ability to control effects from some microbes capable of activating autoimmune and inflammatory reactions. This new work is leading us to the development of an entirely new generation of therapeutics treating autoimmunity and inflammation.

Related publications (1)

BAFF-driven autoimmunity requires CD19 expression

KA Fairfax, E Tsantikos, WA Figgett, FB Vincent, PS Quah, M LePage, ML Hibbs, F Mackay

2015-08-01

B cell activating factor of the tumor necrosis factor family (BAFF or BLyS) is a critical factor for B cell survival and maturatio..